Dr. Betty Lacy, M.D.

Bredesen Program: The End of Alzheimer's thumbnail image


The Bredesen program brings HOPE:

Dr. Dale Bredesen’s work first came on my radar in 2016. I had already been throwing myself into late nite web searching for anything that would change the course of the Alzheimer’s Disease that was affecting both my mother and father. I knew about insulin resistance and had started my mother on intranasal insulin. I re-started her back on the estradiol that had been discontinued 5 years earlier. I don’t know how but this article appeared literally out of nowhere, “Reversal of Cognitive Decline”, a study done at UCLA was published in October 2014 with 10 people, all showing improvement. All were placed on a multimodal program of lifestyle factors and optimization of blood levels of vitamins and hormones and other biomarkers. I was spellbound. I had already been adding to my mother’s regimen supplements like citicoline for synaptic strength, estradiol, exercise, lowering carbohydrates, MCT Oil, and more. These were some of the same interventions he was using. At least I was on the right track. Dr. Bredesen's research and this subsequent UCLA study were responsible for giving me hope along with a host of other people dealing with the ravages of Alzheimer's disease.

From Dr. Bredesen, I learned about how Alzheimer’s Disease (AD) was not one disease but a number of diseases with distinct symptom complexes. I learned that AD lingers in the nervous system in an asymptomatic phase for 10-20 years. Dr. Bredesen uses a metaphor for the brain of a roof with 36 holes, which all need to be fixed before you could see improvement in cognition. Those 36 holes were the gist of the program called Re-CODE; These were the factors that needed to be optimized in order for the brain to come back on-line again. Once optimized the brain could re-boot and start functioning again.

Dr B, as many of us on the APOE4.info site call him, was the first to coin the term a “Cognoscopy”. This is a test he recommends and believes we should all have access to. It can be an annual or done every few years, depending on age and symptoms. to begin when one turns 45 years of age. Like a Colonoscopy, an intervention to prevent colon cancer, a Cognoscopy measures our cognitive health. Complete with biomarkers, genetic testing, MRI (with volumetrics) and neuropsychological testing, a Cognoscopy, would examine how healthy our brains are, identify at-risk individuals for dementia and establish a baseline. Health Care providers would be trained to administer the tests and recommend interventions that would serve to promote cognitive health and prevent cognitive decline. This Brain-Body health program is based on Dr. Bredesen’s protocol for a Cognoscopy.

The table below summarizes lab tests and treatments used to address the five causes of cognitive decline:

  1. Insulin Resistance
  2. Inflammation/Infections
  3. Hormones, nutrient, and trophic factor optimization
  4. Toxins (chemical, biological and physical)
  5. Restoration and protection of lost (or dysfunctional) synapses

Optimize Sleep 7 - 8 hours

Melatonin 0.5 mg nightly; Tryptophan 500 mg 3x/wk if awakening.

Night Rest 1-2 @ HS. Exclude sleep apnea.

Ensure Nocturnal Oxygenation

Sleep study


Brain Training: 30 minutes 3 times a week, or 10-20 minutes 5 to 6 times a week.

Posit APP, BrainHQ APP, Luminosity APP, performance greater than 50% of people among your age

Cognitive Enhancement

See supplements below

Brain Stimulation

Learn a new language, music, dance


Aerobic 30-60 minutes, 5-6/wk

Strength Training 2x/week

Make sure you in your aerobic zone


Minimize Simple Carbohydrates, Implement the Ketogenic Diet

low-glycemic/ low inflammatory/ low grain diet, enhances autophagy

Ketoflex 12/3, Target Ketosis 0.5-4 mmo/L

Fast 12 hours each night, including 3 hours prior to bed

BMI (Body Mass Index) 18-22

High BMI increases risk of inflammation


Stress Reduction

Meditation, Mindfulness Practices, Yoga, Tai Chi, Tention/Trauma Releasing Exercises; Heart Math


Curcumin 1 g twice a day, empty stomach or with good fats

Anti-inflammatory benefits, anticoagulation side effects, Reduction of A-beta

Ashwagandha 500 mg twice per day with meals

Reduction of amyloid beta

Bacopa Monnieri 250-500 mg twice per day with meals

Cognitive enhancement

Magnesium Threonate

Cognitive enhancement

H.- Erinaceus (Lion's Mane) 500 mg once or twice per day

or ALCAR (alpha L-carnitine) 500 mg per day

Increase nerve growth factor

Lithium Orotate 5 - 10 mg at night

Increase nerve growth factor

Gotu kola 500 mg twice per day with meals

For alertness and focus

Citicoline 250 mg twice a day

Provide synaptic structural components

Resveratrol 100 mg each day

Increase SirT1 Function

Nicotinamide riboside 100 mg

Increase Sirtuins, increase mitochondrial function

Shankhpushpi (skullcap) 2 capsules per day

Enhance branching of neurons in the hippocampus


Vitamin B12 Methylcobalamin 1000mcg.

Level 500-1500 pg/ml; reduction of homocysteine/inflammation improves cognitive functioning

Vitamin B9 L-Methyl-folate 1000 mcg

Level 10-25 ng/ml Correction of MTHFR genetic variation: L-Methyl-folate, reduction of homocysteine

Vitamin B6 Pyridoxine

Level 60-100 mcg/l reduction inflammation/homocysteine,

Vitamin B1 50 mg

Important for memory function

Vitamin C 1000 mg

For those with suboptimal Vitamin C levels or copper: zinc ratios greater than 1:2

Vitamin D 2500 IU per day

Level to 50 - 80

Vitamin E 400 - 800 IU

When vitamin E levels are less than thirteen

Vitamin K2, as MK7 100 mcg.

If taking vitamin D3


Exclude Heavy Metal Toxicity (mercury, lead, cadmium)

Chelate if indicated

If Heavy Metals or Biotoxins, Such as mold, Identified

Follow detoxification protocol

Remove any mold from your environments

Follow de-tox protocol: Read "Mold and Mycotoxins" Neil Nathan MD

PROBIOTICS 5 core species of bacteria TREATMENT

Target Lactobacillus Plantarum

Regulates immunity, reduces gut inflammation: maintains nutrients

Target Lactobacillus Acidophilus

Immune enhancement, reduces yeast infections, improves cholesterol

Target Lactobacillus Brevis

Increases BDNF, improves immune function

Target Bifidobacterium Lactis

Reduces food-borne pathogens, enhances immunity, improves digestion

Target Bifidobacterium Longum

Reduces pathogens, improves cholesterol

Probiotic Products for the Nose; ProbioMax ENT and Restore

Restores an optimal microbiome


Optimize Estradiol with Bio-identical Cream or Patch

Increases Hippocampal volume; level 40-60 pg/ml

Optimize Progesterone

Prometrium 100-200 mg at bedtime, balance to Estradiol level ratio

Optimize Pregnenolone

Increases energy; level 50-100 ng/dL
Optimize Testosterone

Supports synaptic maintenance; level total testosterone: 24-45 ng/dL for women; 500-1000 ng/dL for men

Optimize DHEA

Regulates synapses; level 200 mcg/dL for women; 300-350 mcg/dL for men

Optimize Thyroid

Improves energy/memory; levels FT3 = 3.2-4.2(pg/ml), RT3 = 8-25, TT3 = <20, ratio FT3 to RT3:>20; FT4 1.3-1.8, TSH = <2.0

Optimize Vitamin D3

Improves inflammation; level 60-70 ng/ml

Increase Daily Stimulation and Correction With Others

Attend groups, classes, volunteer, and be involved in healthy relationships

1) Do Not Focus on Numbers of Targeted End Results: Many times patients are discouraged by their current levels, keep in mind that the goal is never too far away no matter where you start. AD treatment is a long and continuous process.

2) Always be Aware of Where You Are in the Process: Keep track of when you are improving, where you stand, and when things need to be adjusted.

3) Be Open to Discuss: Now is the best time to get help on your symptoms. Take advantage of today's social networks, such as the Internet and health coaches. Be kind to your body.

4) “Stick With the Program:” The best results were an outcome of people who committed to the program. You have to maintain the protocol in order to achieve the intended goals because the protocol contains many elements only achievable over time.

5) Start at Your Own Pace: At first the list may seem intimidating however it is a process, therefore adopt a number of easy elements that you will be able to maintain before adding in more aspects of the protocol.

Links > Dr. Bredesens Protocol Official Website

Links > The End of Alzheimer’s: The First Program to Prevent and Reverse Cognitive Decline

Links > Sleep Scientist Warns Against Walking Through Life 'In An Underslept State'

Betty Lacy, M.D.

Dr. Lacy specializes in the field of brain health, cognitive resiliency, genetics, and mental health. Learn More >

Brain Body Health Mission

Empowering seekers of knowledge in the subject of brain health and cognitive resiliency to become curious citizen scientists, learning together how to optimize our BRAIN-BODY Health and prevent dementia.

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